Fracture-related infection (FRI) is a challenging complication in orthopaedic trauma, often leading to bone destruction, implant failure, and prolonged treatment. This project (DONUT – Development of advanced Osteolysis Model drive by NeUTrophils) aims to advance understanding by developing a novel human-relevant 3D in vitro model that integrates spatially organized bone constructs, immune cell populations, controlled introduction of Staphylococcus aureus, and advanced molecular and imaging-based readouts. The project will provide mechanistic insights into infection-induced osteolysis and a platform for testing new therapeutic strategies.
Tasks
- Develop and optimise 3D biofabricated bone model with immune cells
- Establish infection models with Staphylococcus aureus
- Introduce and study neutrophil-driven inflammatory processes
- Apply advanced analytical techniques (e.g. imaging, transcriptomics, cytokine profiling)
- Analyse and interpret experimental data
- Contribute to scientific publications and presentations
Requirements
- Master’s degree in biomedical engineering, biology, microbiology, or a related field
- Experience in cell culture and laboratory techniques (e.g. molecular biology, microscopy, microbiology)
- Experience in neutrophil handling and culture
- Experience in planning and executing research experiments
- Strong interest in infection biology, immunology, and/or biomaterials
- Excellent communication skills in English
- Ability to work independently as well as collaboratively in an interdisciplinary environment
- High motivation and enthusiasm for research
- Additional desirable skills: Experience with 3D cell culture or tissue models
- Knowledge of host–pathogen interactions or infection models
- Familiarity with biofabrication, hydrogels, or biomaterials
- Exposure to advanced imaging or omics approaches
Benefits
- An interesting and varied job in an exciting and innovative organization
- The opportunity to be part of a highly committed international team
- Modern infrastructure
- High degree of flexibility regarding working hours and location (depending on operational requirements)
- Generous package of social benefits, including supplementary vacation days and pension scheme contributions
- Internal skills training opportunities and support for continued education
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Das Team
The organization brings together people from diverse backgrounds and specialist areas, united by a passion for excellence and dedication to improving patient care. The AO fosters a close relationship with its medical community, academic societies, and universities, providing a supportive research environment for AO clinicians.