The Laboratory of Toxicology at the Department of Health Sciences and Technology, ETH Zurich, is seeking a motivated PhD student to focus on genomic biomarkers of health and disease. The group aims to understand biochemical and cellular mechanisms governing the bioactive properties of chemicals to promote the function and safety of food, drugs, and personal care products. Researchers develop and apply quantitative chemical, in vitro, and computational approaches to address problems in toxicology.
The group develops and applies bioanalysis approaches to map DNA damage at single-base resolution and integrates multi-omic approaches to characterize DNA damage in the context of genome organization and function. The goal is to mechanistically dissect the role of DNA damage in aging and disease using clinically relevant biological material.
Tasks
- Expand research to uncover biomarkers of aging, a process driven by DNA damage.
- Use DNA sequencing and related methods to characterize cellular responses to stress and following interventions.
- Integrate data using bioinformatics with characteristics such as gene expression and DNA methylation.
Requirements
- MSc or equivalent in Chemistry, Chemical Biology, Toxicology, Pharmaceutical Sciences, Food Science, Molecular Biology, Microbiology, or a closely related discipline (obtained or expected before starting).
- Good written and oral communication skills in English.
- Self-dependent mindset and good leadership qualities.
- Strong foundation of practical relevant laboratory experience.
- Bioinformatics skills are beneficial but can be expanded during the PhD.
- Students who excel in the chemical biology of nucleic acids, genomic sequencing, in vitro toxicology, or related topics are particularly encouraged to apply.
Benefits
- ETH Zurich supports your professional development and contributes to positive change in society.
- Public transport season tickets and car sharing.
- Wide range of sports offered by the ASVZ.
- Childcare and attractive pension benefits.
- Inclusive culture that promotes equality of opportunity, values diversity, and nurtures a respectful working and learning environment.
- Commitment to sustainability and working towards a climate-neutral future.
Bist du Teil dieses Unternehmens?
Dieses Unternehmensprofil wurde automatisch erstellt. Wenn du für ETH Zürich arbeitest, kannst du das Profil jetzt beanspruchen und verifizieren – kostenlos und in wenigen Minuten.
Über uns
Das Team
The Laboratory of Toxicology at the Department of Health Sciences and Technology addresses mechanisms of genome instability from diverse physical and chemical exposures, including environmental, lifestyle, drug, cellular metabolism, and oxidative stress factors.