The Neurotechnology Group at ETH Zurich is recruiting PhD students for a newly funded LOOP Zurich Flagship Project focused on advancing breakthrough technology for non-invasive targeted drug delivery to the brain. The laboratory has developed a novel focused ultrasound-mediated targeted drug delivery platform, enabling localized, hyper-efficient delivery of therapeutic compounds to specific brain regions without invasive surgery. The long-term goal is to establish this technology as a clinically applicable therapeutic platform by integrating targeted drug delivery with advanced neuroimaging, electrophysiology, and closed-loop neuromodulation.
Tasks
- Further develop the focused ultrasound-mediated targeted drug delivery platform.
- Investigate therapeutic potential for neurological disorders.
- Perform preclinical validation in rodent and large-animal models.
- Contribute to the preparation of first-in-human clinical studies.
- Development of next-generation focused ultrasound systems.
- fMRI-guided treatment planning and targeting.
- Optimization of targeted drug delivery and therapeutic dosing.
- Development of closed-loop ultrasound neuromodulation systems.
- Design of custom hardware and software.
- Electrophysiology and multimodal neurophysiology.
- Rodent and large-animal neuroscience experiments.
- Translation of the technology toward clinical application.
- Collaboration with clinicians to prepare first-in-human clinical studies.
- Medical device development and regulatory approval.
Requirements
- Master’s degree in Biomedical Engineering, Electrical Engineering, Mechanical Engineering, Physics, Neuroscience, Computer Science, Chemistry, or a closely related field.
- Excellent academic record.
- Strong quantitative and analytical skills.
- Experimental laboratory experience (e.g., biomedical engineering, neuroscience, chemistry, optics, electrophysiology, or related fields).
- Programming experience (Python, MATLAB, C++, or similar).
- Interest in developing novel biomedical technologies.
- Strong motivation for translational neuroscience and medical innovation.
- Experience with mechanical design, machining, prototyping, or building custom experimental setups is highly desirable.
- Previous experience with focused ultrasound, fMRI, electrophysiology, medical imaging, robotics, drug delivery, or biomedical instrumentation is advantageous.
- Willingness to participate in animal experiments.
Benefits
- The Neurotechnology Group at ETH Zurich provides one of Europe’s leading research environments for neurotechnology.
- Access to high-field 7 Tesla MRI, two-photon and confocal microscopy, state-of-the-art electrophysiology, brain-machine interfaces, mechanical and electronic prototyping workshops, advanced microfabrication facilities, chemical synthesis laboratories, cell culture facilities, behavioral neuroscience laboratories, and small- and large-animal research facilities.
- Collaboration with scientists and clinicians across ETH Zurich, the University of Zurich, University Hospital Zurich, and Klinik Lengg.
- Enrollment as a PhD student in the Department of Information Technology and Electrical Engineering (D-ITET) at ETH Zurich, membership in the Institute of Neuroinformatics, and the Neuroscience Center Zurich (ZNZ) PhD Program.
- ETH Zurich encourages an inclusive culture, promotes equality of opportunity, values diversity, and nurtures a respectful working and learning environment.
- Sustainability is a core value, with consistent efforts towards a climate-neutral future.
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Das Team
The Neurotechnology Group integrates expertise in neuroscience, biomedical engineering, physics, electrical engineering, medical imaging, robotics, and translational medicine. The project is conducted in close collaboration with Swiss Epilepsy Clinic Lengg, the Department of Neurosurgery at University Hospital Zurich, and the Vetsuisse Faculty of the University of Zurich.