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The Neurotechnology Group at ETH Zurich is recruiting postdoctoral researchers and PhD students for a newly funded LOOP Zurich Flagship Project aimed at advancing a breakthrough technology for non-invasive targeted drug delivery to the brain. The laboratory has developed a focused ultrasound-mediated targeted drug delivery platform that enables localized, hyper-efficient delivery of therapeutic compounds to specific brain regions without invasive surgery. The project integrates carrier formulation chemistry, chemical engineering, medical imaging, real-time sensing, and intelligent control into a unified system, establishing a new paradigm for precision neurotherapeutics and opening opportunities for treating various neurological disorders.

Tasks

  • Design and synthesis of ultrasound-responsive drug carrier formulations (e.g., microbubbles, nanodroplets, liposomes, or polymeric/lipid nanoparticles)
  • Optimization of drug loading, encapsulation efficiency, and release kinetics
  • Physicochemical characterization of carriers (size, zeta potential, stability, morphology)
  • Chemical engineering of carrier production processes (e.g., microfluidics, emulsification, sonication)
  • Assessment of carrier stability under ultrasound exposure and physiological conditions
  • In vitro and in vivo evaluation of drug loading, release, and therapeutic efficacy
  • Analytical method development for carrier and drug quantification (e.g., HPLC, DLS)
  • Integration of carrier formulations with focused ultrasound delivery systems
  • Collaboration with engineers and clinicians to prepare first-in-human clinical studies
  • Contribution to regulatory-compliant formulation development and quality control

Requirements

  • Applicants for the PhD position should hold a Bachelor’s degree and preferably also a Master’s degree
  • Applicants for the postdoctoral position should hold a PhD in Chemical Engineering, Chemistry, Pharmaceutical Sciences / Pharmaceutics, Materials Science, Biomedical Engineering, or a closely related field
  • Excellent academic records from excellent institutions
  • Strong quantitative and analytical skills, including programming (Python, MATLAB, or similar)
  • Experimental laboratory experience in drug formulation, nanoparticle/microbubble synthesis, colloid chemistry, or related fields
  • Hands-on experience with carrier characterization techniques (e.g., dynamic light scattering, zeta potential, HPLC, electron microscopy)
  • Microfluidic synthesis/purification expertise
  • Knowledge of drug loading, encapsulation efficiency, and release kinetics assessment
  • Strong motivation for translational drug delivery research and medical innovation
  • For postdoctoral applicants, a track record of peer-reviewed publications in drug delivery, nanomedicine, or pharmaceutical sciences
  • Good communication skills
  • Ability to work independently as well as part of a multidisciplinary team
  • Animal experiment experience (e.g., in vivo drug delivery studies, small animal handling, surgical procedures, imaging, or pharmacokinetic/biodistribution assessment) is considered positively
  • Previous experience with focused ultrasound, drug delivery, or biomedical instrumentation is considered positively
  • Willingness to participate in animal experiments

Benefits

  • The Neurotechnology Group at ETH Zurich provides one of Europe’s leading research environments for neurotechnology and drug delivery
  • Laboratory facilities include chemical synthesis and drug formulation laboratories, high-field 7 Tesla MRI, two-photon and confocal microscopy, state-of-the-art electrophysiology, brain-machine interfaces, mechanical and electronic prototyping workshops, access to advanced microfabrication facilities, cell culture facilities, behavioral neuroscience laboratories, and small- and large-animal research facilities
  • Collaboration with scientists and clinicians across ETH Zurich, University of Zurich, University Hospital Zurich, and Swiss Epilepsy Clinic Lengg
  • PhD candidates will be enrolled in the Department of Information Technology and Electrical Engineering (D-ITET) at ETH Zurich, affiliated with the Institute of Neuroinformatics, and the Neuroscience Center Zurich (ZNZ) PhD Program
  • Postdoctoral researchers will be affiliated with the Institute of Neuroinformatics
  • ETH Zurich encourages an inclusive culture, promotes equality of opportunity, values diversity, and nurtures a respectful working and learning environment
  • Sustainability is a core value, with ongoing efforts towards a climate-neutral future
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Über uns
Die ETH Zürich ist eine technisch-naturwissenschaftliche Hochschule des Bundes mit Sitz in Zürich. Wir betreiben Lehre, Forschung und Wissenstransfer in Bereichen wie Ingenieurwissenschaften, Naturwissenschaften, Architektur, Mathematik, Informatik, Management sowie Sozial- und Geisteswissenschaften. Unsere Ausbildung umfasst Bachelor-, Master-, Doktorats- und Weiterbildungsangebote und ist eng mit internationaler Spitzenforschung verbunden. Als Teil des ETH-Bereichs entwickeln wir wissenschaftliche Grundlagen, Technologien und Lösungen für Gesellschaft, Wirtschaft und globale Herausforderungen.
Das Team

The Neurotechnology Group collaborates closely with scientists and clinicians from ETH Zurich, University of Zurich, University Hospital Zurich, and Swiss Epilepsy Clinic Lengg. PhD candidates and postdoctoral researchers are affiliated with the Institute of Neuroinformatics and participate in interdisciplinary research teams.

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