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Biomarkers are critical components of translational research, enabling robust therapeutic and mechanistic hypothesis testing in early clinical development, and as precision medicine enablers such as defining patient subpopulations, predicting patient responses, and use as diagnostics. The Therapeutic Area Head in Biomarker Development in Translational Medicine partners with Disease area, Translational Medicine, Global Development, and Commercial leadership for the development and implementation of innovative, complex, exploratory biomarker strategies, independent of clinical program stage, and provides an effective interface for transitioning projects to later stage development.

Tasks

  • Identify, develop, and drive disease, mechanistic biology, translational pharmacology and precision medicine approaches for the Neuroscience and DARe (Diseases of Aging and Regenerative medicine) portfolio, leveraging diverse biomarker modalities such as genetics, genomics, proteins, cells, imaging, digital devices and technology/data science strategies.
  • Strategic decision-making and executive oversight in indication/patient selection, biomarker strategy formulation, and investigations into drug mechanisms of action.
  • Deliver clinical project and disease biology "fit for purpose" biomarker strategies/plans across the Neuroscience and DARe portfolio and lead reviews at Disease Area Decision Boards, Biomarker Forum, Biomarker and Diagnostic Review Committee, TDSCs and governance boards.
  • Lead, mentor and develop a dedicated group of biomarker project team leads and therapeutic area biomarker leads to develop and oversee clinical project strategies, plans and timelines.
  • Provide Novartis disease biomarker leadership internally and externally to drive innovative mid-long term disease area initiatives/consortium across biomarker/clinical study designs, endpoints, diagnostics and discovery strategies.
  • Provide insight into optimal selection of exploratory, "fit for purpose" and validated biomarkers across modalities to address clinical and biological mechanism questions, trial endpoints and identify responsive patient subpopulations.
  • Collaborate closely with other functions in Biomedical Research and Development to provide expertise, optimize portfolio value and issue resolution.
  • Contribute to and review study protocols, clinical study reports, Integrated Development Plans, and Clinical Pharmacology Plans.
  • Support high quality internal and regulatory submissions/decisions such as proof of concept/mechanism, dose selection/escalation, safety and competitive differentiation claims.
  • Attend meetings with external parties including investigators, outside experts, and health authorities, as needed.

Requirements

  • PhD and/or MD desirable with broad biology/technology knowledge in the clinical biomarker field; medical and/or clinical genetics experience desired.
  • Deep expertise in drug development.
  • Substantial impactful experience working in Pharma and/or biotechnology R&D business functions, leading internal and external high performing diverse teams and matrix organizations.
  • Scientific excellence and clinical expertise in neurodegeneration, neuroimmunology, neuromuscular and neurogenetic diseases/biology evidenced by significant contributions to the field.
  • Demonstrated technical and scientific expertise in multiple areas for development of innovative biomarker solutions with experience in working across key modalities (e.g. xRNA, AAV, biotherapeutics and small molecules).
  • Well-developed interpersonal skills with good presence and ability to influence and negotiate with senior leadership, experienced presenter and communicator.
  • Strong track record of people leadership.
  • Recognized internally and internationally externally by key stakeholders; in depth understanding of external environment/trends; develops a strong professional network.
  • Fluent in oral and written English; other languages such as German, French, Italian useful but not required.

Benefits

  • Expected annual base salary range: 169,400.00 - 314,600.00 CHF.
  • Base salary determined based on gender-neutral objectives, relevant skills, competencies and experience in accordance with Novartis pay setting policy and reviewed periodically.
  • Eligible for performance-based bonus depending on certain performance parameters.
  • Competitive benefits in kind such as insurance plans, retirement plans, wellbeing resources and global recognition programs.
  • Flexible and hybrid working options, where possible.
  • Minimum 14 weeks paid parental leave.
  • Long-term equity awards granted at group level may also be part of the package.
  • Pay equity is a fundamental principle of employment policy, supporting a diverse, equitable and inclusive environment.
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Über uns
Novartis ist ein international tätiges Schweizer Pharma- und Biotechnologieunternehmen mit Sitz in Basel und entwickelt, produziert und vertreibt innovative Arzneimittel. Das Unternehmen konzentriert sich auf Forschung und Entwicklung in verschiedenen Therapiegebieten wie Onkologie, Neurologie und Immunologie und bringt neue Therapien für Patienten weltweit auf den Markt. Novartis ist global tätig und zählt zu den führenden Unternehmen im Gesundheitssektor.
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