The Modeling & Simulation group within PK Sciences is seeking a Principal Scientist to Associate Director level modeler to develop and apply translational physiologically based pharmacokinetic (PBPK) modeling and data analysis techniques to support drug discovery, development, and translational research across disease areas. The goal is to be at the forefront of applying PBPK models to inform safe administration of drug candidates in the clinic, optimize clinical trial designs, and accelerate getting medicines to patients.
Tasks
- Provide expert PBPK modeling support for global drug discovery and development projects.
- Perform translational PBPK analyses to predict clinical drug exposure in specific populations, assess potential for drug-drug interactions (DDI), understand clinical impact of disease on drug exposure, and apply biopharmaceutic PBPK modeling to support formulation changes and achieve clinical biowaivers.
- Integrate PK/PD data, ADME and DDI findings.
- Interpret and communicate modeling results and potential impact to project teams.
- Prepare summary documents for regulatory submissions and respond independently to health authority questions.
Requirements
- PhD in pharmaceutical sciences or related discipline with experience in ADME/DMPK sciences, biopharmaceutics, and modeling and simulation.
- At least 5+ years in the pharmaceutical industry, including demonstrated knowledge and experience with PBPK modeling.
- Hands-on experience with PBPK modeling tools such as PK-Sim, Simcyp, or GastroPlus is required.
- Experience with modeling software such as Monolix, R, Phoenix, or Nonmem is desired.
- Experience in authoring regulatory documents and knowledge of global regulatory requirements and guidance.
- Broad knowledge of drug discovery and development, including pharmacokinetics, drug delivery, formulation, ADME, and DDI.
- Experience with regulatory submissions and successful regulatory interactions.
- Interdisciplinary thinking and great attention to detail.
- Ability to work in a dynamic and multidisciplinary environment.
- This is a hybrid role requiring an average of 12 days a month on site in Basel, Switzerland.
- Candidates with demonstrated impact as a modeler, preferably in the pharmaceutical/biotech industry, and with commensurate experience and proficiency may be considered for the Principal Scientist II (5+ years) or Associate Director (8+ years) role.
Benefits
- Expected annual base salary range: 122,500.00 - 227,500.00 CHF.
- Base salary determined by relevant skills, competencies, and experience, reviewed periodically.
- Eligibility for a performance-based bonus depending on certain performance parameters.
- Variety of competitive benefits including insurance plans, retirement plans, wellbeing resources, and global recognition programs.
- Flexible and hybrid working options, where possible.
- Minimum 14 weeks paid parental leave.
- Long-term equity awards may be part of the package.
- Pay equity is a fundamental principle of employment policy.
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Über uns
Das Team
The Modeling & Simulation group within PK Sciences offers a dynamic and multidisciplinary environment for building, verifying, and applying quality translational/biopharmaceutical PBPK models.