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We are looking for an experienced Scientist in Oligonucleotide Chemistry to architect and optimise lead candidates for therapeutic drug discovery. You will champion the rational design and chemical modification framework for next-generation oligonucleotides, collaborating with multidisciplinary teams.

Tasks

  • Design and champion the rational chemical modification framework for next-generation oligonucleotides, including siRNAs and ASOs, to advance critical drug discovery projects.
  • Collaborate with computational experts and synthesis teams to create high-value, novel oligonucleotide libraries, bridging theoretical chemistry with data-driven design.
  • Analyze experimental data using advanced computational methods, applying continuous learning cycles to refine and elevate chemical designs.
  • Translate innovative chemical concepts into synthetically accessible structures with precision and attention to detail.
  • Stay at the forefront of emerging technologies and external breakthroughs to identify novel ways to improve safety profiles, durability, and therapeutic performance.
  • Partner across multidisciplinary teams, including biology, pharmacology, and toxicology, to evaluate biological impacts and guide strategic decisions in a collaborative environment.

Requirements

  • You hold a Ph.D. in Oligonucleotide Chemistry, Organic Chemistry, or a related discipline, complemented by 3 to 5 years of industry experience in the biotech or pharmaceutical sectors.
  • Experience across different oligonucleotide modalities is highly desirable.
  • You bring deep expertise in translating chemical modifications of oligonucleotides into innovative drug candidate designs.
  • You possess a comprehensive understanding of modern oligonucleotide modification patterns (such as 2'-O-methyl, 2'-fluoro, LNA, cEt) and how they influence therapeutic properties.
  • You are familiar with delivery technologies (like GalNAc, lipid, or peptide conjugates), and any insights you have into linker design are highly valued.
  • You combine scientific creativity and attention to detail with independent problem-solving skills.
  • You thrive in a collaborative environment where you can inspire and guide cross-functional teams.

Benefits

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally.

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Über uns
Roche ist ein international tätiges Schweizer Pharma- und Diagnostikunternehmen mit Sitz in Basel und entwickelt, produziert und vertreibt Medikamente sowie diagnostische Lösungen. Das Unternehmen ist in den Bereichen Pharma und Diagnostik tätig und fokussiert sich auf Forschung und Innovation in verschiedenen Therapiegebieten wie Onkologie, Neurologie und Infektionskrankheiten. Roche ist weltweit aktiv und zählt zu den führenden Unternehmen im Gesundheitsbereich.
Das Team

In Roche’s Pharmaceutical Research and Early Development organization (pRED), the mission is to transform science into medicines. The Therapeutic Modality (TMo) organization translates disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines, driving innovation through cross-disciplinary collaboration.

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