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We aim to pursue a new interdisciplinary approach, combining the synthesis of multi-functional culture-matrices with cell-instructive viscoelastic properties, in-depth cell characterisation, and computational modelling to investigate the relationship between matrix properties and osteogenesis. This will contribute to deciphering the importance of mechanical stimulation of the cellular microenvironment and advance understanding of osteoinductive scaffold development in bone tissue engineering.
Tasks
- Rationally engineer hydrogels tuned to the specific mechanical requirements for osteogenesis.
- Dissect how targeted manipulation of the hydrogel affects mechanoregulation in human dental pulp stem cells.
- Propose a computational model to elucidate and predict the cell response.
- Engineer environmentally (cell)-instructive hydrogels with controlled architecture (pore size, network interconnectivity) and mechanical properties (viscoelasticity) to recapitulate the mechanical micro-environment of the jawbone.
- Work with mechanosensitive complexes within the hydrogel that form stimuli-responsive cross-links, adjusting hydrogel viscoelasticity as a function of cytoskeletal tension to guide cell growth.
- Combine experimental work with computational modelling to understand and predict correlations.
Requirements
- Highly self-driven with a hands-on work attitude.
- Interest in pursuing an interdisciplinary project in biology, tissue engineering, material science, and chemistry.
- Master in Nanosciences, Biomedical Engineering, Health Sciences and Technology, Biology, Chemistry, or similar, from an institute of higher education accepted by the University of Basel.
- Experience in mammalian cell culture and analysis (Microscopy, qRT-PCR).
- Experience in hydrogel formulations and characterisation (Rheometry, Atomic Force Microscopy).
- Experience in data analysis and graphical representation (GraphPad, MATLAB, R or similar).
- Fluency in English and good communication skills.
Benefits
- Fully paid PhD position, affiliated with the Swiss Nanoscience Institute, University of Basel, with a salary based on the guidelines from the Swiss National Science Foundation.
- Close guidance from supervisor and co-supervisor as well as technical and administrative support.
- Possibilities for collaborative work within the Medical Faculty and the Faculty of Science.
- Access to state-of-the-art core facilities for FACS, Confocal Microscopy and the Nano Imaging Lab for electron microscopy.
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Über uns
Die Universität Basel ist eine international ausgerichtete Schweizer Hochschule mit einem breiten Angebot an Bachelor- und Masterstudiengängen in Natur-, Geistes-, Sozial- und Rechtswissenschaften, Medizin sowie Wirtschaft. Neben der akademischen Ausbildung betreibt sie Forschung in zahlreichen Disziplinen. Zielgruppen sind Studieninteressierte, Studierende, Doktorierende und Wissenschaftler.