A fully funded postdoctoral position is available in the Dixon Lab at the University of Basel to investigate how the nervous system shapes anti-tumour immunity and the tumour microenvironment. The lab studies neuro-immune communication in cancer, focusing on how peripheral neurons sense changes in tissue state and regulate immune-cell function. Join a collaborative and international environment to help shape the future of biomedicine.
Tasks
- Lead an ambitious interdisciplinary project at the interface of immunology, neuroscience, and cancer biology.
- Investigate how neural pathways regulate immune responses within tumours and how neuro-immune circuits can be manipulated to improve anti-tumour immunity.
- Research directions may include: how peripheral sensory or autonomic neurons regulate dendritic-cell and T-cell function; neuronal sensing of inflammatory and tumour-derived signals; neuropeptide and neurotransmitter regulation of anti-tumour immunity; neural control of immune-cell trafficking, activation, and persistence within tissues; identification of neuro-immune signalling pathways that promote or restrain tumour growth; functional validation of new therapeutic targets at the neuro-immune interface.
- Utilise experimental approaches such as in vivo tumour models, conditional mouse genetics, neuronal tracing, genetic and viral manipulation of neuronal populations, immune-cell depletion and adoptive transfer, spectral flow cytometry, cell sorting, imaging, transcriptomics, single-cell RNA sequencing, spatial transcriptomics, and functional neuro-immune assays.
Requirements
- PhD in immunology, cancer immunology, neuroimmunology, molecular biology, or a related discipline.
- Strong conceptual and experimental background in immunology.
- Substantial hands-on experience with in vivo mouse models.
- Extensive experience with flow cytometry and immune-cell phenotyping.
- Strong record of experimental research, ideally including a high-quality first-author publication.
- Ability to design, execute, and interpret mechanistic experiments independently.
- Strong scientific communication skills and ability to work effectively in an interdisciplinary environment.
- Experience in tumour immunology, dendritic-cell biology, T-cell biology, mouse genetics, peripheral neuroscience, neuronal tracing, viral vectors, single-cell genomics, spatial biology, or advanced imaging is advantageous.
- Prior training in neuroscience is not required.
- Candidates with a strong immunology background who are excited to move into the emerging field of cancer neuroimmunology are strongly encouraged to apply.
Benefits
- A stimulating, interdisciplinary research environment focused on neuro-immunology in cancer.
- Dynamic and international team with a strong culture of collaboration and mutual support.
- Close interaction with neighboring labs in neuroscience, immunology, oncology, and cancer immunology.
- Strong mentorship, including career development support and guidance toward independent research careers.
- Intellectual freedom to develop computational methods and scientific ideas.
- Access to excellent infrastructure for flow cytometry, animal experimentation, advanced microscopy, single-cell sequencing, spatial transcriptomics, and computational biology.
- Extensive opportunities for collaboration within Basel and internationally.
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Über uns
Das Team
The Dixon Lab is based at the Department of Biomedicine, University of Basel, within a highly interactive research environment spanning immunology, cancer biology, neuroscience, genomics, and translational medicine. The team combines mechanistic in vivo immunology with neural circuit approaches, single-cell technologies, and spatial biology to understand how the nervous and immune systems communicate in health and disease.