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The University of Zurich, Switzerland's largest university, offers an inspiring working environment focused on cutting-edge research and top-class education. Join a project aiming to advance next-generation CAR immune cell therapies against malignant brain tumors, with direct patient impact.
Tasks
- Generate CAR immune cell communities, comprising mixtures of engineered T cells, NK cells, monocytes, and additional cell types, using sophisticated in vitro and in vivo engineering platforms.
- Identify co-factors that boost CAR immune cell function using cutting-edge screening platforms.
- Investigate anti-tumor activity and immune-cancer-cell environmental crosstalk in vitro and in vivo using disease models such as organoids, slice cultures, patient-derived samples, and mouse models, employing technologies including flow cytometry, multiplexed imaging, spatial transcriptomics/proteomics, and single-cell profiling.
- Analyze patient samples from an accompanying clinical trial evaluating CAR immune cell communities.
Requirements
- Intellectual curiosity, creativity, and a proactive approach to problem-solving.
- Motivation to contribute to a project with direct patient impact.
- PhD in immunology, computational immunology, cell/molecular/cancer biology, bioengineering, biomedical sciences, or a related field.
- Experience with immune cell engineering, cellular immunotherapy, and/or advanced in vitro/in vivo disease models is highly desirable.
- Familiarity with single-cell and/or spatial technologies is a plus.
- Strong publication record demonstrating scientific productivity.
- Excellent communication skills and the ability to thrive in an interdisciplinary team.
Benefits
- Flexible working models such as part-time positions, mobile working, and job-sharing.
- Childcare at the kihz foundation of UZH and ETH.
- Wide range of continuing education courses of UZH and the Canton of Zurich.
- Language Center run jointly with ETH Zurich.
- Food and drinks at reduced prices in the UZH cafeterias.
- Lunch-Check-card with UZH contribution.
- Special conditions on the Academic Sports Association ASVZ.
- Free seasonal flu vaccinations.
- Rest and relaxation at the quiet room in the university tower.
- Discounts on carsharing, vehicle rental, parking space, hardware, software, and mobile phone subscriptions.
- Policies of the UZH for conditions of employment.
- Support for people from outside Switzerland through International Services.
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Über uns
Die Universität Zürich ist eine öffentliche Universität des Kantons Zürich und bietet Lehre, Forschung und Weiterbildung in einem breiten Spektrum wissenschaftlicher Disziplinen an. Sie umfasst sieben Fakultäten und verbindet akademische Ausbildung mit Grundlagenforschung, angewandter Forschung, Nachwuchsförderung und Wissenstransfer. Die UZH arbeitet mit nationalen und internationalen Hochschulen, Forschungsinstitutionen, Spitälern, Unternehmen und öffentlichen Stellen zusammen und leistet Beiträge in Bereichen wie Medizin, Naturwissenschaften, Wirtschaft, Recht, Gesellschaft, Geisteswissenschaften und Theologie.