Data Scientist / Engineer - DNA-Encoded Library Technology (DELT)

Advance scientific data analysis and develop automated workflows for small-molecule drug discovery by joining Roche's Pharmaceutical Research and Early Development organisation (pRED). Collaborate with multidisciplinary teams to transform complex screening data into actionable insights at the intersection of chemical biology, cheminformatics, and data science. Roche values personal expression, open dialogue, and genuine connections, aiming to prevent, stop, and cure diseases while ensuring access to healthcare for all.

• Advance DELT data analytics by applying robust statistical methods, predictive models, and advanced analytical approaches to interpret large-scale DEL screening datasets, identify promising chemical starting points, and support hit and lead discovery programs.
• Develop intuitive, accessible analytical tools and workflows that empower DELT screening scientists and project teams to rapidly evaluate selection results, prioritise compounds, and make informed experimental decisions.
• Design, implement, and maintain automated, reproducible data processing and analysis pipelines that transform complex experimental outputs into reliable, decision-ready insights.
• Develop computational workflows and searchable building-block data resources to support chemical space exploration, reaction prediction, library design, and synthesis strategy optimisation.
• Partner closely with experimental scientists, computational chemists, and machine learning teams to translate evolving scientific challenges into scalable computational solutions.
• Communicate scientific insights by presenting analytical results, computational approaches, and technical developments clearly to scientific and multidisciplinary audiences, supporting knowledge sharing and adoption of new capabilities.
• Champion scientific excellence by promoting reproducibility, data integrity, and robust engineering practices while contributing to a safe and compliant research environment.

• You are highly passionate about DNA-encoded library technology, pushing the boundaries of the field, as well as discovering and taking on new challenges.
• You are a highly motivated data scientist with strong enthusiasm for chemical biology and advancing technology, interested in performing state-of-the-art research in the pharmaceutical industry.
• You hold a PhD or M.S. in Bioinformatics, Statistics, Computer Science, Data Science, Cheminformatics, Software Engineering, or a related quantitative field.
• You have a strong software engineering background with experience deploying pipelines at scale in HPC or cloud platforms.
• You possess proven experience in high-throughput scientific data analysis (preferably with large-scale screening data, DEL selection outputs, or NGS processing pipelines) and a demonstrated ability to architect reliable, user-friendly tools that simplify complex analytical workflows for non-expert scientists.
• You demonstrate strong proficiency in Python and statistical programming, along with expertise in data visualisation frameworks (e.g., Spotfire, Tableau, or modern web dashboarding tools).
• You bring an understanding of hit-triaging, noise reduction, statistical ranking, and signal verification in large-scale datasets, with demonstrated capability in cheminformatics (including handling chemical structures, building-block metadata, or toolkits like RDKit/OpenEye) and laboratory data systems (LIMS, SQL, relational databases), integrating computational tools with experimental workflows as a plus.
• You are a critical thinker and problem solver with a continuous improvement mindset and a track record of conceptualising scalable scientific solutions, paired with strong communication skills to translate complex quantitative findings for multidisciplinary and non-quantitative stakeholders.

At Roche, you are valued, accepted, and respected for who you are, allowing you to thrive both personally and professionally. Roche is an Equal Opportunity Employer.

Roche is dedicated to advancing science and ensuring access to healthcare for everyone, with more than 100,000 employees worldwide. The company delivers life-changing healthcare solutions, treating over 26 million people with its medicines and conducting over 30 billion diagnostic tests globally.

The DELT team is part of Molecular Discovery Technologies within the Small Molecule Research Discovery (SMRD) department, under Therapeutic Modalities (TMo) in Roche Pharma Research and Early Development (pRED). The team collaborates across disciplines to drive innovation and deliver high-quality chemistry starting points for small-molecule projects.